Cooperating to Unlock the Voltage-dependent K Channel
نویسندگان
چکیده
منابع مشابه
Cooperating to Unlock the Voltage-dependent K Channel
Opening the Shaker K channel should be easy. Release the membrane potential that normally holds it closed, and massive stored molecular energies snap it rapidly and inexorably into its open configuration. Unlocking the inner secrets of this voltage-dependent channel’s gating mechanism has proven to be much more difficult. An article by Ledwell and Aldrich in this issue has opened that door sign...
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The voltage-gated delayed-rectifier-type K+ channel Kv2.1 is expressed in high-density clusters on the soma and proximal dendrites of mammalian central neurons; thus, dynamic regulation of Kv2.1 would be predicted to have an impact on dendritic excitability. Rat brain Kv2.1 polypeptides are phosphorylated extensively, leading to a dramatically increased molecular mass on sodium dodecyl sulfate ...
متن کاملVoltage - dependent Structural Interactions in the Shaker K 1 Channel
Using a strategy related to intragenic suppression, we previously obtained evidence for structural interactions in the voltage sensor of Shaker K 1 channels between residues E283 in S2 and R368 and R371 in S4 (Tiwari-Woodruff, S.K., C.T. Schulteis, A.F. Mock, and D.M. Papazian. 1997. Biophys . J . 72:1489–1500). Because R368 and R371 are involved in the conformational changes that accompany vol...
متن کاملVoltage-Dependent Structural Interactions in the Shaker K+ Channel
Using a strategy related to intragenic suppression, we previously obtained evidence for structural interactions in the voltage sensor of Shaker K(+) channels between residues E283 in S2 and R368 and R371 in S4 (Tiwari-Woodruff, S.K., C.T. Schulteis, A.F. Mock, and D. M. Papazian. 1997. Biophys. J. 72:1489-1500). Because R368 and R371 are involved in the conformational changes that accompany vol...
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We have studied the effect of Rb+ on K channel closing kinetics in toadfish pancreatic islet cells. These channels are voltage dependent, activating at voltages positive to -10 mV. The channels also inactivate upon prolonged depolarizations, and the inactivation time course is best fit by the sum of two exponentials. Instantaneous current-voltage relationships show that external Rb+ enters the ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1999
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.113.3.385